Effect of Proteinuria Degree (Below and Above 1g/day) on Survival in Patients with IgA Nephropathy

Immunglobulin A nefropathy is the most widely encountered primary glomerular disease in the world and ıs one of the maın causes of ESRD. Aim of our study is to identify the effect of proteinurıa level to survey during their diagnosis in the patients who are diagnosed as Ig A nefropathy by renal biopsy.
Fifty two patients, who were diagnosed by renal biopsy and followed in our nefrology clinic between 2002 and 2010 were included in our study.Patients first 1 st,3 rd ,6 th ,12 th ,24 th month and last arterial blood pressure ,urea ,creatinin ,glomerul filtration rate (by short MDRD formula) proteinurıa level for 24 hours and the treatment patients got during their following were all recorded. Patients were divided in two groups those whose proteinurıa was lower and higher than 1 gr/day. While findings from the study were being evaluated NCSS 2007 & PASS 2008 Statistical software programme was used for the statistical analyses.
Starting creatinin level was 1,02±0,32 mg/dl and last creatinin level was 0,90±0,15 mg/dl for those whose proteinürıa level is <1 gr/day. Starting creatinin level was 1,34±0,96 mg/dl and last creatinin level was 1,33±0,82mg/dl (p<0.05) for those whose proteinürıa level is > 1gr/day. Starting GFR was 83,58 ±27,17 ml/min and last GFR was 89,35±19,06 ml/min (p=0,80) for cases whose proteinürea level is <1gr/day. Starting GFR was 77,43 ± 30,97 ml/min and last GFR was 71,60±28,30 ml/min (p=0,008) for cases whose proteinürıa level is > 1 gr/day. Starting proteinürıa level was 0,34 ± 0,2 gr/day, last proteinurıa level was 0,28 ± 0,25 gr/day (p=0.06) for cases whose proteinurıa level < 1gr /day. Starting proteinurıa level was found as 2,20 +-1,41 gr/day and last proteinuria level was found as 1,05 ± 1,56 gr/day (p=0,02) for cases whose proteinurıa level > 1gr. Durıng their followıng cases whose proteınurıa < 1gr/day didn’t need dialiysis and 3 cases whose proteinurıa level is > 1 gr/day needed dialysis programme.
1st,3rd,6 th,12th,24th, month and last creatinin level of cases whose starting poteinurıa level is 1 gr and above is found to be statıstıcally significantly higher than those cases whose proteinurıa level is under 1gr, Complete remission rate is high in those whose proteinurıa level is under 1 gr. Result of our study have shown that there is a significant relationship between the level (higher and below 1 gr/day ) of proteinurıa and survey in Ig A nefropathy.